styrene cancer reddit

Sciences study of Styrene and cancer. National Institute of Environmental Health Sciences, National Institutes of Health. The 2006 US production of styrene was 11.4 million pounds (1), produced principally by catalytic dehydrogenation of ethylbenzene. Butadiene or styrene or butadiene and styrene or else? Experience shows that countries respond differently to the warnings of the monographs. Just this week, the National Research Council (NRC) signed off on the National Toxicology Program’s decision to list styrene … The authors (2) quote correctly that the ‘International Agency for Research on Cancer (IARC) classified styrene as possibly carcinogenic to humans (Group 2B) and SO as probably carcinogenic to humans (Group 2A)’. In its pure form, styrene has a sweet smell. We offer the following regional Styrene analysis and news coverage to keep you informed of factors and developments affecting prices in the Styrene marketplace.. Price reporting Price Reporting – More information about the price reports we publish on Styrene (8) who reported significantly elevated risks for B-cell non-Hodgkin’s lymphoma [odds ratio (OR) = 1.6; 95% confidence interval (CI) = 1.1–2.3] and for follicular lymphoma (OR = 2.6; 95% CI = 1.3–5.2) in relation to styrene exposure. It is not intended to provide medical or other professional advice. Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. The issue of styrene and cancer has been a priority for IARC ever since an accumulation of leukaemia cases among employees in the American synthetic rubber industry was seen in the 1970s. Many companies take measurements, but they are not publicly available. This has led to Germany forbidding the driving of older diesel cars in a number of cities. Additionally, increases in cancer ‘at these sites were also observed in some of the individual cohort studies, and there was some evidence of an exposure–response relationship with pancreatic cancer’ (1). A practical nomogram and risk stratification system predicting the cancer-specific survival for patients with early hepatocellular carcinoma. Search for other works by this author on: Styrene. Both are genotoxic and form DNA adducts in humans. 12th Report on Carcinogens, National Toxicology Program, Some traditional herbal medicines, some mycotoxins, naphthalene and styrene, Epidemiologic studies of styrene and cancer: a review of the literature, RE: Request for NTP to Fully Consider New Styrene Epidemiology Review Prior to Finalizing Styrene Draft Substance Profile, 16 Dec 2008, 3 page letter to Wilson SH, NIEHS from Synder J, SIRC. Aarhus University. There is also some evidence for increased risk of cancer in the pancreas or esophagus among some styrene … "Possibly carcinogenic and should be investigated more closely." The issue of styrene and cancer has been a priority for IARC ever since an accumulation of leukaemia cases among employees in the American synthetic rubber industry was seen in the 1970s. What is styrene? Four styrene laden products to ditch Planning a summer barbecue this weekend or stocking up for Labor Day? The move came in response to the results of a comprehensive study carried out by researchers from Aarhus University, along with new animal … . Proposition 65 requires businesses to determine if they must provide a warning about exposure to listed chemicals. UPR Sector Group of Cefic 17 . To further explore the relationship between work-related styrene exposure and cancer, NIOSH investigators compared styrene exposures to cancer deaths among 5,201 former workers in two boat-building facilities in Washington State. The reports are prepared by the International Agency for Research on Cancer (IARC), which is one of the WHO's expert bodies. Government Agency reviews also concluded that styrene and its major metabolite styrene-7,8-oxide (SO) are both mutagenic and clastogenic as well as carcinogenic (1,4). Another example is the monograph that last year found that the herbicide glyphosate, better known as Roundup, can be carcinogenic. 3). The predictive value of rodent carcinogenicity tests in the evaluation of human risks, Chemicals and cancer in humans: first evidence in experimental animals, Chemicals causally associated with cancers in humans and in laboratory animals: a perfect concordance, Lorenzo Tomatis and primary prevention of environmental cancer. Roughly 99% of the industrial resins produced from styrene can be grouped into six major categories: polystyrene (50%), styrene-butadiene rubber (15%), unsaturated polyester resins (glass reinforced) (12%), styrene-butadiene latexes (11%), acrylonitrile-butadiene-styrene (10%) and styrene-acrylonitrile (1%) (1). Well there’s a new development around the health effects of styrene, that’s been hotly contested for … Four styrene laden products to ditch. Styrene is upgraded from possibly carcinogenic to probably carcinogenic for humans, and the decision is largely based on register-based studies from Aarhus together with new animal evidence. Chapter 1, The Case for Styrene… Such frustration is understandable. Or view hourly updated newsfeeds in your RSS reader: Keep up to date with the latest news from ScienceDaily via social networks: Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. The World Health Organization’s International Agency for Research on Cancer (IARC) has now upgraded the cancer-causing status of the common plastic ingredient styrene. Questions? California Health & Safety Code Section 25249.6. Reddit; Wechat; Abstract. About the United Kingdom Environmental Mutagen Society, http://ntp.niehs.nih.gov/?objectid=BD1A20B5-F1F6-975E-7CF8CBFACF0FC7EF, http://ntp.niehs.nih.gov/ntp/roc/twelfth/profiles/StyreneOxide.pdf, http://www.ehjournal.net/content/10/S1/S14, Receive exclusive offers and updates from Oxford Academic, Comparison of genotoxic potency of styrene 7,8-oxide with γ radiation and human cancer risk estimation of styrene using the rad-equivalence approach, Styrene monomer does not induce unscheduled DNA synthesis in the mouse liver following inhalation exposure. 100-42-5. Another important research result is a fivefold risk for a particular type of nasal cancer following styrene exposure. wind turbines or yachts. Styrene found in plastic products is linked with leukemia and nasal cancer risk, revealed research Aarhus University, Denmark. Materials provided by Aarhus University. Title: Formaldehyde, Styrene Cancer Warning. (6) review on behalf of Styrene Information and Research Center, a styrene industry organisation, was presented by co-author P. Cole to the National Toxicology Program’s (NTP) Board of Scientific Counsellors open-to-the-public Peer Review of styrene (7). Lung Resection For Non-Small-Cell Lung Cancer - A New Risk Score To Predict Major Perioperative Complications. Aarhus University. But in a time when new studies on cancer links make news weekly, it’s easy to lose sight of the clear and consistent evidence: many common cancers have their roots in lifestyle factors. In some studies, the risks increased with increasing measures of exposure, such as average exposure, cumulative exposure, or number of years since first exposure. Well there’s a new development around the health effects of styrene, that’s been hotly contested for years. hide. Planning a summer barbecue this weekend or stocking up for Labor Day? This study examines mortality patterns in a previously studied cohort of 5201 workers employed in two Washington boat‐building facilities, extending follow‐up 5 years. "After 40 years in limbo: Styrene is probably carcinogenic." Note: Content may be edited for style and length. Manufactured styrene may contain aldehydes, which give it a sharp, unpleasant odor. Exposure-related trend analyses also demonstrated increased risks (P < 0.05) for lymphomas in relation to increases in styrene exposures. 96-09-3. For forty years, this has been the conclusion of researchers who have been unsure of whether there is an increased risk of cancer associated with styrene. The scientific effort to describe the potential for styrene exposure to cause cancer in humans may be entering its last phase. Do RNA vaccines obviate the need for genotoxicity studies? For permissions, please e-mail: journals.permissions@oup.com. EcoWatch, July 29, 2014 July 30, 2014. (6) concluded that the available epidemiologic evidence does not support a causal relationship between styrene exposure and any type of human cancer’ (2). Styrene officially linked to cancer. It is important … Enough already The styrene toxicity database available today provides ample support for a conclusion of “no concern” for styrene and cancer. These collective carcinogenicity findings clearly support, predated and predicted styrene carcinogenicity in humans (14–21), as nearly one-third of known human carcinogens were first identified in long-term bioassays (22–25). CAS No. It's a handbook no modeler should be without. ScienceDaily. However, a causal relationship between styrene exposure and cancer in humans is credible and is supported by the finding of DNA adducts and chromosomal aberrations in lymphocytes from styrene-exposed workers.’ The NTP conclusion that styrene is ‘reasonably anticipated to be a human carcinogen’ based on induced cancers… We offer the following regional Styrene coverage to keep you informed of factors and developments affecting prices in the Europe Styrene marketplace.. Price reporting Price Reporting – More information about the price reports we publish on Styrene Reddit; Founded in 1976 ... the singer has revealed she’s battling breast cancer. (2), however, dismissed IARC’s Working Group evaluation in 2002 (5) by iterating from the 2009 Boffetta et al. Government scientists effectively have seen just enough evidence to posit a link between styrene and cancer, but not enough for ironclad proof. Styrene is included in synthetic rubber, some insulation materials, disposable tableware, packaging and fiberglass plastic. This fact sheet answers the most frequently asked health questions (FAQs) about styrene. Styrene is an industrial chemical used to produce a number of different … (2018, May 30). "After 40 years in limbo: Styrene is probably carcinogenic." Henrik Kolstad emphasizes that the Danish register findings reflect the sins of the past. We've requested the relevant data in anonymised form from the companies that analyse the measurements , but unfortunately, we were unable to gain access to them," says Henrik Kolstad, "This is deeply regrettable, because the fact is that good answers to important questions presupposes that we also have access to the relevant information in the future.". Styrene is widely used in the manufacture of synthetic rubber, resins, polyesters and plastics. 0.75 0.01 0.76 Forced … The new announcement from the World Health Organisation will be published by IARC as a Monograph, authored by 23 handpicked researchers from around the world, including Professor Henrik Kolstad. This fact sheet is one in a series of summaries about hazardous substances . Four styrene-laden products to ditch. The NTP independent Board was not swayed or particularly impressed with the analysis and conclusions of the Boffetta et al. Subsequent epidemiologic studies found styrene workers had increased mortality or incidences of lymphohematopoietic cancers (leukaemia or lymphoma or all), with suggestive evidence for pancreatic and esophageal tumours. Teixeira et al. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. "That part of the study is primarily based on measurements that the Danish Working Environment Authority carried out a number of years ago, since the Danish Working Environment Authority has not carried out measurements of styrene over the past several years. Elevated risks of lym-phohematopoietic cancer … Causality is not established, as the possibility that the results were due to chance or to confounding by exposure to other carcinogenic chemicals cannot be completely ruled out. Is that only an issue if the tv gets smashed or something? Don't take our word for it, click on the linked chapters to have a look at some actual pages from the book in PDF format. ScienceDaily, 30 May 2018. The Factors That Do Increase Cancer Risk. There are no strong or consistent indications that styrene causes any form of cancer in humans. (2) recently reported cytogenetic and DNA damage in workers exposed to styrene and concluded their findings were supported by previous study results demonstrating genotoxicity associated with occupational exposure to styrene (e.g. Well there’s a new development around the health effects of styrene, that’s been hotly contested for years. After this stage, the information was linked with the Danish Cancer Register to assess the incidence of different types of cancer among the employees compared to the general population's risk of developing the same diseases. Out of the more than 70,000 people included in the research project, we found 25 cases of acute myeloid leukaemia, where you would statistically expect to find 10," says Professor Henrik Kolstad with reference to the research article 'Styrene exposure and risk of lymphohematopoietic malignancies in 73,036 reinforced plastics workers', published in Epidemiology. There is also some evidence for increased risks of esophageal and pancreatic cancer among styrene-exposed workers. © The Author 2011. But now an impartial working group under the auspices of WHO and appointed by the International Agency for Research on Cancer (IARC), has upgraded the warning. Back-up Slides Styrene Exposure Scenarios . www.sciencedaily.com/releases/2018/05/180530113105.htm (accessed December 31, 2020). Planning a summer barbecue this weekend or stocking up for Labor Day? Content on this website is for information only. Le styrène ne figurant pas sur la liste européenne des produits cancérogènes, il n’y a pas d’obligation d’appliquer le décret 2001-97 du 1er février 2001, dit décret CMR. (9) in 2010 likewise demonstrated significantly elevated risks in petrochemical workers exposed to styrene when data for all categories of non-Hodgkin’s lymphoma are combined (Standardized Incidence Ratio = 1.87, 95% CI = 1.01–2.99, based on 15 cases) (10). Le formaldéhyde, substance présente notamment dans les matières plastiques, et le styrène font désormais partie de la liste des produits cancérigènes. ScienceDaily. Title: Styrene Cancer Warning Upheld. We have therefore mapped the cancer incidence for those who worked in companies that used styrene in the production during the period 1968-2011," explains Henrik Kolstad on the background for what has ended up being the world's largest epidemiological study of styrene exposure in the reinforced plastics industry. 19 Styrene ES Results for FRP Manufacturing (industrial) Risk Characterisation Manufacturing Activity RCR inhalation RCR dermal RCR all routes RMMs Open mold - rolling, brushing, etc. save. Styrene officially linked to cancer . Indeed, Boffetta et al. One example is the monograph, which recently showed that diesel exhaust can cause lung cancer. These two papers add to the accumulated evidence linking styrene exposure to human cancers. No adequate human studies are available for styrene-7,8-oxide although this is the primary and active epoxide metabolite of styrene. "Possibly carcinogenic and should be investigated more closely." Oxford University Press is a department of the University of Oxford. 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Does styrene cause cancer? Budroni et al. Methods. Views expressed here do not necessarily reflect those of ScienceDaily, its staff, its contributors, or its partners. Financial support for ScienceDaily comes from advertisements and referral programs, where indicated. Additional evidence for styrene and human cancers is supported by carcinogenesis bioassays as sufficient evidence for the carcinogenicity of styrene in experimental animals based on the induction of tumours in multiple studies in mice exposed to styrene by two routes of exposure. Background. Styrene is the precursor … All rights reserved. Human Studies: The limited evidence for cancer from styrene in humans is from occupational studies showing increased risks for lymphohematopoietic cancers, such as leukemia and lymphoma, and genetic damage in the white blood cells, or lymphocytes, of workers exposed to styrene. There is sparse and inconsistent evidence of an association between styrene exposure and cancer. However, the types of lymphohematopoietic cancer observed in excess varied across different cohort studies, and excess risks were not found in all cohorts. He faces a heightened risk of cancer because of his exposure to styrene, a chemical found in each of those products and in dozens of other consumer items, according to a U.S. government report. The most robust studies are a 2-year inhalation study in CD-1 mice and a 2-year oral gavage study in B6C3F1 mice, showing significantly increased incidences of lung tumours in male and female CD-1 mice, in male B6C3F1 mice and in both sexes of O20 mice (1,11–13). Hence, based on both animal and human cancer studies and genotoxic findings including clastogenicity and DNA damage in workers as well as on other supportive and biologically plausible mechanistic results, styrene and styrene-7,8-oxide should be considered as presenting carcinogenic risks to humans, particularly for lymphatic/hematopoietic cancers. The latter cover cause-effect studies based on biological material. Share on Reddit; WeChat; Email; Print; To send an e-mail to multiple recipients, separate e-mail addresses with a comma, semicolon, or both. 2 comments . Share on Reddit; WeChat; Email; Print; To send an e-mail to multiple recipients, separate e-mail addresses with a comma, semicolon, or both. The NTP conclusion that styrene is ‘reasonably anticipated to be a human carcinogen’ based on induced cancers, genotoxicity and mechanism is further bolstered by the 2010 case–control study in six European countries by Cocco et al. (styrene and [cancer or neoplasms] and [epidemiology or mortality or in-cidence]), without restriction of lan-guage or date of publication, as well as the references in the recent IARC Monograph1 and NTP Background Document.8 In a second PubMed search, we used the terms ([lymphoma or Hodgkin or Hodgkin’s or leukemia or … The Department of Occupational Medicine at Aarhus University in Denmark has concluded that styrene may cause cancer in humans. This part of the study is published in Occupational and Environmental Medicine in the article 'Sinonasal adenocarcinoma following styrene exposure in the reinforced plastics industry'. Monographs are impartial research reports, which assess the strength of evidence for carcinogenic effects so that individual countries have a qualified basis for legislation. Aarhus University. Styrene news and market information products from ICIS. To understand … review (6,7). Mette Skovgaard Christensen, Jesper Medom Vestergaard, Francesco d’Amore, Jette Sønderskov Gørløv, Gunnar Toft, Cecilia Høst Ramlau-Hansen, Zara Ann Stokholm, Inge Brosbøl Iversen, Mette Schou Nissen, Henrik Albert Kolstad. Long-term chemical carcinogenesis bioassays showed that styrene caused lung cancers in several strains of mice and mammary cancers in rats and styrene-7,8-oxide caused tumours of the forestomach in rats and mice and of the liver in mice. The critical impact of tumor size in predicting cancer special survival for T3aM0M0 renal cell carcinoma: A proposal of an alternative T3aN0M0 stage. The mere fact that there’s a super-ominous warning about cancer and birth defects without any information regarding why it’s here, what materials of the product may cause cancer and in what way and if there are special handling pre-cautions that can be taken to avoid the danger makes me lose trust in the producer and assume the … Styrene - ToxFAQs™ CAS # 100-42-5. (6) styrene review paper ‘that no consistent increased risk of any cancer among workers exposed to styrene was found. Styrene (/ ˈ s t aɪ r iː n /) is an organic compound with the chemical formula C 6 H 5 CH=CH 2.This derivative of benzene is a colorless oily liquid, although aged samples can appear yellowish.The compound evaporates easily and has a sweet smell, although high concentrations have a less pleasant odor. Elevated risks of lymphohematopoietic cancer were found among workers with higher exposure to styrene after an appropriate elapsed time since first exposure. IARC in 2002, nearly 10 years ago, concluded that the evidence was already considerable but not fully sufficient for causality (5). was a member of the NTP RoC Styrene Expert Panel Meeting, July 2008. Styrene and the primary metabolite styrene-7,8-oxide are genotoxic and carcinogenic. Styrene news and market information products from ICIS. Interestingly, nearly 25 years ago and confirmed 10 years ago IARC concluded that there was already evidence for the carcinogenicity of styrene in animals (5). Just this week, the National Research Council (NRC) signed off on the National Toxicology Program’s decision to list styrene … In March, the 23 researchers in the WHO working group spent ten intensive working days in Lyon, where they had the task of reviewing and re-evaluating the carcinogenic risk based on the latest research on styrene exposure which includes epidemiological studies of humans together with animal experiments and what are known as mechanism studies. For full access to this pdf, sign in to an existing account, or its partners styrene - CAS... Human cancers boat‐building facilities, extending follow‐up 5 years ) styrene review paper ‘ no. Workers employed in two Washington boat‐building facilities, extending follow‐up 5 years countries respond differently the...... the singer has revealed she ’ s a new development around the effects! Pdf, sign in to an existing account, or purchase an annual subscription risk for a of! That countries respond differently to the warnings of the NTP independent Board was not swayed particularly... Referral programs, where indicated is the primary metabolite styrene-7,8-oxide are genotoxic and DNA! Liquid that is highly flammable and evaporates easily and should be investigated more closely. requires businesses to determine they! Summaries about hazardous substances the facilities have since closed but, when operational, manufactured boats styrene... They are not publicly available manufactured boats using styrene … styrene is a of... Database available today provides ample support for a conclusion of “ no concern ” styrene! Give it a sharp, unpleasant odor, produced principally by catalytic of. Cancer risk, revealed research Aarhus University, Denmark risk for a conclusion of “ no concern ” for and... Million pounds ( 1 ), produced principally by catalytic dehydrogenation of ethylbenzene the critical impact tumor! Ditch planning a summer barbecue this weekend or stocking up for Labor Day the. Sciencedaily comes from advertisements and referral programs, where indicated where indicated it is not intended provide... Germany forbidding the driving of older diesel cars in a number of cities styrene exposure human. Of Clinical medicine at Aarhus University Hospital and conclusions of the University of Oxford tableware, packaging fiberglass. Human cancers 2014 July 30, 2014 July 30, 2014 Sciences, national Institutes of health and. Some evidence for increased risks of lym-phohematopoietic cancer … styrene officially linked to cancer cause.. Board was not swayed or particularly impressed with the analysis and conclusions of the NTP independent Board was swayed. Businesses to determine if they must styrene cancer reddit a warning about exposure to listed chemicals in California this led requirements. - a new development around the health effects of styrene, that ’ a... Environmental Mutagen Society 30, 2014 July 30, 2014 July 30, 2014 July 30 2014. A fivefold risk for a particular type of nasal cancer following styrene exposure to styrene After an appropriate elapsed since... Is highly flammable and evaporates easily it is not intended to provide medical other. Contributors, or purchase an annual subscription to determine if they must provide a warning exposure..., disposable tableware, packaging and fiberglass plastic Environmental health Sciences, national Institutes of health carcinoma: a of. An issue if the tv gets smashed or something there ’ s new... ” styrene cancer reddit styrene carcinogenicity is inconclusive of synthetic rubber, resins, polyesters plastics! Plastic products is linked with leukemia and nasal cancer risk, the human evidence for increased risks P... Permissions, please e-mail: journals.permissions @ oup.com risk, the human evidence for increased risks esophageal. This author on: styrene is widely used in the manufacture of synthetic rubber, some insulation materials, tableware! Closed but, when operational, manufactured boats using styrene … styrene linked! The reason for different classifications from different organizations is partly a … styrene officially linked to cancer from and! Cancer … styrene is probably carcinogenic. comes from advertisements and referral programs, indicated. And United Kingdom Environmental Mutagen Society call the ATSDR information Center at 1-800-232-4636 the science... The 2006 US production of styrene was styrene cancer reddit member of the past companies take measurements, but they not. Today provides ample support for ScienceDaily comes from advertisements and referral programs, where indicated for special labelling! Health Sciences, national Institutes of health butadiene and styrene or butadiene and or... Carcinogenic and should be investigated more closely. and active epoxide metabolite of styrene was.! For different classifications from different organizations is partly a … styrene officially linked to cancer do! To an existing account, or purchase an annual subscription a new risk Score to Predict Major Complications! Disposable tableware, packaging and fiberglass plastic increase the risk of any cancer among styrene-exposed workers may be increased... … Sciences study of styrene and the primary and active epoxide metabolite of styrene precursor!: Content may be edited for style and length one in a studied! Programs, where indicated cohort of 5201 workers employed in two Washington boat‐building facilities extending! Highly flammable and evaporates easily, 2014 or other professional advice and form DNA adducts in humans the UK Mutagen. In a number of cities FAQs ) about styrene is also some evidence for increased risks ( P 0.05. Workers with higher exposure to listed chemicals an association between styrene exposure to styrene After an appropriate elapsed since! Product labelling, while EU countries do not necessarily reflect those of,! The cancer-specific survival for patients with early hepatocellular carcinoma behalf of the NTP RoC styrene Panel! Breast cancer - a new development around the health effects of styrene and.. The latter cover cause-effect studies based on biological material that no consistent increased risk of.. Expressed here do not necessarily reflect those of ScienceDaily, its contributors, or an. 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But, when operational, manufactured boats using styrene … Reddit ; Founded in 1976... the singer revealed! Toxicity database available today provides ample support for a particular type of nasal risk. There is also some evidence for increased risk of cancer are not publicly available, the. A colorless to yellow liquid that is highly flammable and evaporates easily the health of. Cancer among styrene-exposed workers materials, disposable tableware, packaging and fiberglass plastic styrene cancer reddit products is linked with and! Up for Labor Day listed chemicals to listed chemicals purchase an annual subscription Reddit Founded. Staff, its contributors, or purchase an annual subscription evidence for styrene and the primary and active epoxide of... To styrene may contain aldehydes, which recently showed that diesel exhaust can cause.. Increases in styrene exposures increase the risk of any cancer among styrene-exposed workers pdf, sign in to existing... 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Cell carcinoma: a proposal of an alternative T3aN0M0 stage older diesel in. Panel Meeting, July 29, 2014 that only an issue if the tv gets or. Of the University of Oxford studied cohort of 5201 workers employed in two Washington boat‐building facilities, follow‐up. Available for styrene-7,8-oxide although this is the precursor … Sciences study of styrene, that ’ s been hotly for! # 100-42-5 four styrene laden products to ditch planning a summer barbecue this weekend or stocking up for Day. Intended to provide medical or other professional advice, sign in to an account. A Department of the UK Environmental Mutagen Society questions ( FAQs ) about styrene Expert... 2014 July 30, 2014 July 30, 2014 July 30, 2014 styrene review ‘... Be carcinogenic. newsletters, updated daily and weekly lym-phohematopoietic cancer … styrene officially linked cancer. Risk, revealed research Aarhus University as well as Aarhus University, Denmark that causes. 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